Phosphatidylserine: The Brain-Boosting Nutrient You Need to Know

In today’s fast-paced world, maintaining optimal brain health has become more important than ever. Whether you're a student striving for academic excellence, a professional juggling multiple tasks, or an older adult aiming to preserve cognitive function, the need for effective brain support is universal.

Phosphatidylserine, an essential phospholipid, is one of the active compounds in brain boosting supplements that support memory, focus, and overall cognitive performance.

 

What is Phosphatidylserine?

Phosphatidylserine (PS) is a naturally occurring phospholipid — a fat-like substance that forms part of the structure of cell membranes, especially in the brain. It plays a critical role in keeping brain cells healthy and supporting communication between them. PS also activates protein kinases, which are signalling molecules involved in memory and learning processes in the brain.

While our bodies produce small amounts of PS, levels can decline with age. That’s where supplementation comes in.

Backed by Science: Cognitive Support at Any Age

A 2025 randomized controlled trial by Duan et al. revealed that daily supplementation of two capsules (including 63 mg of phosphatidylserine) over 12 months significantly improved cognitive performance in adults aged 65 and above. Participants showed better memory, attention, and overall mental clarity.

Previous studies also highlight PS's potential benefits in younger adults under stress, improving focus and reducing mental fatigue.

5 Key Benefits of Phosphatidylserine

1. Boosts Memory

PS helps maintain the fluidity of brain cell membranes, essential for memory formation and recall. It’s particularly helpful in age-related memory decline.

2. Improves Focus and Mental Clarity

Struggling to stay focused? Phosphatidylserine supports neurotransmitter activity, helping you think clearly and stay on task — naturally.

3. Reduces Stress and Cortisol

Studies show PS may help regulate cortisol, the stress hormone. Lower cortisol means better mood, fewer stress-related crashes, and improved mental resilience.

4. Supports Learning and Information Processing

Whether you're studying for an exam or learning a new skill, PS helps speed up the brain’s processing power and enhances learning capacity.

5. Promotes Healthy Aging

PS protects brain cells from oxidative stress and inflammation, supporting long-term cognitive health as you age.

DHA x Phosphatidylserine

High levels of brain omega-3 DHA help phosphatidylserine (PS) accumulate and expand within nerve cell membranes. Adequate DHA is essential for PS to perform its vital functions effectively. Factors such as alcohol consumption, oxidative stress, traumatic brain injuries, vegan or nutrient-poor modern diets, and aging can all increase the brain's need for these essential fats.

Dietary intake of DHA and PS supports a healthy mood, sharper focus, stronger cognitive skills, improved memory, and better stress management — making them a powerhouse duo for brain health. Ensuring sufficient daily intake of omega-3 DHA and phosphatidylserine (PS) helps maintain optimal brain electrical activity and communication pathways.

Natural Sources vs. Supplements

Phosphatidylserine can be found in foods like soybeans, white beans, egg yolks, and organ meats. However, it’s difficult to get enough through diet alone — especially as our natural production declines over time.

That’s why phosphatidylserine supplements (often derived from soy or sunflower lecithin) are a convenient, reliable option for daily brain support.

Who Should Consider Taking Phosphatidylserine?

• Adults over 50 looking to preserve brain health
• Students or professionals needing enhanced focus
• Individuals experiencing brain fog or high stress
• Anyone seeking to support cognitive performance naturally
  

A Smart Addition to Your Brain Wellness Routine

Whether you’re looking to sharpen your mind, support healthy aging, or simply stay focused in a distracted world, phosphatidylserine offers science-backed support your brain will thank you for. As always, consult your healthcare provider before starting any new supplement — especially if you're on medication or managing health conditions.

Stay sharp, stay balanced — and give your brain the care it deserves. For trusted options, explore our curated range of brain booster supplements Singapore designed to deliver efficacy and quality for lasting cognitive support.
Because a clearer mind means a fuller life.

References:

Kay JG and Grinstein S (2011) Sensing phosphatidylserine in cellular membranes, Sensors (Basel), 11(2),1744-1755.

Kim HY, Huang BX and Spector AA (2014) Phosphatidylserine in the Brain: Metabolism and Function, Prog Lipid Res, 1-45.

Duan H, Xu N, Yang T, Wang M, Zhang C, Zhao J, Li Z, Chen Y, Yan J, Zhang M, Li W, Yue Z, Ma F, He R and Huang G (2025) Effects of a food supplement containing phosphatidylserine on cognitive function in Chinese older adults with mild cognitive impairment: A randomized double-blind, placebo-controlled trial, Journal of Affective Disorders, 369, 35-42.